News

Highlights from 2013



December 10, 2013 3rd Millennium announces the completion of the integration of a scheduling system for emergency room providers. The aim of the project was to restructure the information technology environment and the operational practices of a long established leading solution for the management of all scheduling aspects of emergency medicine physicians and providers. While highly functional, the accumulated information technology legacy and standing work practices of the company personnel impeded future growth of the business. Our approach was to perform a complete analysis of the business including the business processes executed by technical personnel and support staff. In parallel, the technical components of the software solution were benchmarked for performance and stability. Based on these analyses, the structure of the business was modified to provide new, enhanced, and more targeted support to the customers of the business. Additionally, the computing environment used by the scheduling software was restructured to operate in a high performance cluster environment, allowing for high availability and a significant increase in performance.



Highlights from 2012



June 25, 2012 3rd Millennium has announced the completion of a system to track laboratory animals. While most animal systems are narrowly focus on animal breeding, lineage and husbandry, our solution adds key elements of laboratory information management system (LIMS) to these basic functions. Through the system, samples and experiments are related to the animals such that the full custody of information is maintained from the animals to the results of the analyses performed on the samples and to the observations made directly on the animals. In addition, detailed genotypic information is maintained in the system allowing parent to offspring comparisons and derivation of correlations between genotypic elements and experimental phenotypes. This integration of animal tracking and LIMS concepts along with additional integration to other research and discovery systems in the client computing infrastructure provides significant efficiencies and facilitates analyses that would otherwise require lengthy manual, time consuming, and error prone processes.



Highlights from 2011



December 21, 2011 3rd Millennium has announces the completion of a system to manage the program book for a global pharmaceutical company. The program book application provides means for researchers and managers across all disease areas in the company to compile, edit, and revise critical summaries of ongoing programs and projects. Automated upload of program book fragments into the corporate document repository ensures proper versioning of the information and facilitates the production of the final program book version on an annual basis. Additionally, the system enforces use of terminology consistent with enterprise wide controlled vocabulary services. The benefits of deploying to system to all disease areas in the enterprise include greatly reduced production time of the program book, a reduced number of edit-review cycles, and overall better quality and accuracy of the information.


June 13, 2011 3rd Millennium announces the successful completion of a proof of concept for the next generation Translational Medicine and Personalized Health Management Knowledge cloud. Through the coordination and management of individual and resources from more than 20 public, private, and non-profit organizations, the team for this project was able to define the foundation of a computationally tractable representations of the meaning and representation of data, and to extend semantic support to analytic and other services so that they can be discovered, understood, and securely utilized. The outstanding effort of the group produced a reference implementation of enterprise-level platform independent models addressing semantic needs, especially the need for behavioral semantics. Thus, the deliverables lays the ground work for dramatically reduced level of effort associated with creation of semantic information, in part by leveraging to the greatest extent possible automated approaches to harvest semantics information from line of business and software engineering activities.



Highlights from 2010



November 1, 2010 3rd Millennium announces that it has been selected to manage the definition of a roadmap and the creation of a proof of concept for a next generation Biomedical Research, Translational Medicine and Personalized Health Management Knowledge cloud. This Knowledge Cloud will be developed with a focus on developing and deploying reference implementations of specifications developed to support Working Interoperability between stakeholders throughout the Knowledge Cloud. Development activities will be focused on utilizing a variety of standards that support and enable Working Interoperability, as well as on utilizing a number of Best Practices drawn from the collective experiences in both the commercial and open-source software engineering communities. The effort will involve the coordination of a large number of stakeholders within the government, academic and commercial research, clinical, and software development spheres.


June 1, 2010 3rd Millennium announces the completion of a roadmap for specifying and implementing a toxicology data warehouse. The goals of the roadmap were to determine the feasibility, technologies, resources, cost and timeframe for creating a unified system capable of handling all pre-clinical toxicology data at a top 15 pharmaceutical company. Toxicology data is extremely diverse with little commonality between the many types of assays used in the development and pre-clinical stages of the pipeline. Furthermore, end user enquiries and requirements vary substantially based on their roles. A successful toxicology data warehouse must be capable of answering both detailed data pull within the context of a single compound as well as broad multi-project, multi-compound queries. The roadmap determined that a single unified model was achievable for all relevant types of assays with sufficient s expressiveness to answer expected queries. Also, it identified that a service oriented architecture was most suitable to handle loading of data from both internal operational systems and contract research organizations, and provide granular security and search capabilities. Finally, the roadmap specified the staging of functionality into multiple coherent specification and implementation phases.



Highlights from 2009



September 1, 2009 3rd Millennium has announced the completion of a analysis information management system (AIMS) for loading data from heterogenous sources into a unified protein data warehouse. At the core of the AIMS is a sophisticated semantic integration engine that unifies several public and proprietary ontologies and knowledge bases. Data processed through the AIMS is semantically normalized by the integration engine prior to loading into the warehouse, ensuring consistent and unambiguous information content in the warehouse. This system was designed and implemented for a large biotechnology company and will be used to direct and monitor ongoing research programs.


May 30, 2009 3rd Millennium has announced the completion of a prototype for the iGenome™ software platform for Individual Genetic Health Assessment.


February 5, 2009 3rd Millennium has announced the completion of a large scale data collection project for a network of hospitals to gather life style and medical information from individuals. The project was performed using an online assement tool and by selecting a best of breed survey software package from Novi Survey Software, the collection of data was performed entirely using web technologies in less than 2 months. A prior data collection effort involving phone interviews had required more than 6 months with less data collected ultimately and significantly more data entry errors.



Highlights from 2008



June 1, 2008 3rd Millennium has been awarded a Phase I Small Business Innovation Research (SBIR) grant from the National Human Genome Research Institute (NHGRI) to build a Software Platform Prototype for Individual Genetic Health Assessment.


March 24, 2008 3rd Millennium has announced the completion of the reengineering of PhosphoSitePlus (www.phosphosite.org), a comprehensive resource provided by Cell Signaling Technology (CST) for information concerning protein modifications and their role in regulating cellular functions. PhosphoSitePlus enables the user to formulate sophisticated queries based on treatments, diseases, cell lines, and tissues, and result in retrieval of bulk data sets. Results of these queries can be downloaded for analysis and model-building. There are provisions for bulk queries that will allow high-throughput labs to determine whether sites from their modification site discovery programs are novel.



Highlights from 2007



October 31, 2007 3rd Millennium announces today that Elaine Freund, Ph.D., formerly the director of Product Management and Application Sciences at Cognia, has joined the Company as Senior Project Scientist. Dr. Freund will lead and coordinate the Integrative Cancer Research workspace (ICR) for the cancer Biomedical Informatics Grid caBIG™ project sponsored by the National Cancer Institute's Center for Bioinformatics NCICB. The goal of the project is to speed the delivery of innovative approaches for the prevention and treatment of cancer.


February 12, 2007 3rd Millennium announced today that the Center for Comparative and Functional Genomics at the University of Illinois has purchased their award winning Array Repository and Data Analysis System (ARDAS). Located in Urbana-Champaign, the center conducts research on the comparative genetic organization, evolution and function of plant, animal and microbial genomes. Press Release


January 15, 2007 3rd Millennium announces today that Kim Fechtel, Ph.D., formerly the Senior Director of Bioinformatics at Genome Therapeutics Corporation, has joined the Company as Senior Director, Scientific Consulting. Dr. Fechtel will be responsible for business development and act as the Principal Investigator and scientific leader for R&D grants.



Highlights from 2006



October 9, 2006 3rd Millennium announced the release of version 2.5 of its ARDAS™ microarray data management system. Version 2.5 of ARDAS includes general usability and performance enhancements and features for bulk loading of data, integration and exports to external resources and software packages such as GoMiner™, DAVID, GeneSpring®, or PathwayStudio®, and enhanced normalization and linear modeling analytical capabilities.


March 15, 2006 3rd Millennium announced today the release of a new version of its award winning ARDAS™ software. The Array Repository and Data Analysis System provides a complete and fully integrated solution to microarray data acquisition, management, and analysis. ARDAS includes a Laboratory Information Management System (LIMS), a repository and data warehouse, and an Analysis Information Management System (AIMS). Press Release



Highlights from 2005



November 1, 2005 3rd Millennium announced today that it has received a prestigious Small Business Innovation Research Quality Award from the department of defense for its ARDAS™ microarray Bioinformatics platform. The award recognizes exceptional projects for their quality, originality, and innovation of research. Press Release


March 1, 2005 3rd Millennium is selected to lead and coordinate the Vocabularies & Common Data Elements workspace VCDE for the cancer Biomedical Informatics Grid caBIG™ project sponsored by the National Cancer Institute's Center for Bioinformatics NCICB. The goal of the project is to speed the delivery of innovative approaches for the prevention and treatment of cancer.


January 1, 2005 3rd Millennium receives a Phase II Small Business Innovation Research (SBIR) contract from the Department of Defense to extend its Microarray Repository and Data Analysis System ARDAS™ with sophisticated analytical workflows and integration to external applications and data sources. Press Release



Highlights from 2004



December 20, 2004 3rd Millennium announces that Brian Davis, Ph. D., formerly Director of Database Development at Proteome, has joined the Company as Senior Project Scientist. Press Release


Aug 10, 2004 3rd Millennium receives additional funding from the Department of Defense to extend its Repository and Data Analysis System ARDAS™ to support additional analysis workflows and to integrate to external 3rd party software and tools.


April 15, 2004 3rd Millennium is selected to lead and coordinate the Integrative Cancer Research workspace (ICR) for the cancer Biomedical Informatics Grid caBIG™ project sponsored by the National Cancer Institute's Center for Bioinformatics NCICB. The goal of the project is to speed the delivery of innovative approaches for the prevention and treatment of cancer.


January 15, 2004 3rd Millennium receives a Phase I Small Business Innovation Research (SBIR) contract from the Department of Defense to continue the development of its Microarray Repository and Data Analysis system ARDAS™.



Highlights from 2003



December 15, 2003 3rd Millennium releases its Knowledge Management System as open source under the GNU General Public License GPL to the Biotech and Pharmaceutical community. Press Release


November 20, 2003 CytRx's subsidiary Araios teams with 3rd Millennium to implement a Scientific Computing Platform for RNAi-Based Diabetes and Obesity Drug Development. Press Release


February 19, 2003 3rd Millennium releases whitepaper titled: Knowledge Management Lagging in Drug Discovery R&D. Press Release


January 27, 2003 3rd Millennium receives Phase II Small Business Innovation Research (SBIR) contract from the Department of Defense to continue development of its Microarray Repository and Data Analysis system ARDAS™. Press Release



Highlights from 2002



October 7, 2002 3rd Millennium announces that Juli Klemm, Ph.D., formerly the Director of Scientific Project Management at Incyte Genomics, has joined the Company as Senior Project Scientist. Press Release


August 6, 2002 The Hereditary Disease Array Group HDAG reported important new findings on Huntington's disease from data compiled in the NeuMetrix gene expression database, which was custom-built by 3rd Millennium. Press Release


June 10, 2002 3rd Millennium collaborates with the Hereditary Disease Foundation Array Group (HDAG) to create the largest publicly-available repository of microarray gene expression data to help accelerate Huntington's disease research. Press Release


May 6, 2002 3rd Millennium releases a whitepaper titled: Practical Data Integration in Biopharmaceutical R&D: strategies and technologies. Press Release


February 13, 2002 3rd Millennium receives Phase I Small Business Innovation Research (SBIR) contract from the Department of Defense to develop an innovative Microarray Bioinformatics System. Press Release



Highlights from 2001



December 4, 2001 3rd Millennium implements a Lab Information Management System System (LIMS) for Ardais Corporation. The new system will support the high throughput pathology lab operations that provide high quality data to their Biorepository Management System. Press Release


November 27, 2001 3rd Millennium announces the completion of a custom Bioinformatics System for Biogen to support the integration, workflow, and analysis needs of their core gene expression facility. Press Release


October 9, 2001 3rd Millennium teams with GeneEd and CHI to create a "Microarray Informatics" courseware based on the workshop presented at the CHI Third Annual Pharmacogenomics Conference. Press Release


August 28, 2001 Physiome Sciences Licenses PathwayPrism™ Biological Modeling Technology to 3rd Millennium for the Development of Models for Huntington's disease. Press Release



Highlights from 2000



October 4, 2000 3rd Millennium Awarded $1.8 Million from ATP for Life Sciences Information Management Program for Pharmaceutical Research and Development to develop state of the art software to integrate, analyze, and organize information from gene-based research conducted by biotechnology and pharmaceutical companies worldwide. Press Release