Press Release

CytRx Subsidiary Teams with 3rd Millennium for Scientific Computing Platform For RNAi-Based Diabetes and Obesity Drug Development

-- Informatics Component key to Accelerating Small Molecule Discovery Efforts --

Los Angeles, CA, Novermber 20, 2003 CytRx Corp. (NASDAQ:CYTR) said today that its subsidiary, Araios Inc., has partnered with 3rd Millennium, Inc. to implement a scientific computing platform for RNAi-based development programs focused on type II diabetes and obesity therapeutics. The system will be used by CytRx scientists to generate focused libraries of compounds for major targets for these diseases.

"Our partnership with 3rd Millennium should significantly enhance our molecular based drug discovery platform in obesity and diabetes," said Steven A. Kriegsman, CEO of CytRx. "In tandem with our strategic relationships with world renowned researchers in RNAi treatment for ALS (Lou Gehrig's Disease), our rapidly expanding efforts in RNAi therapies for obesity and diabetes position CytRx as a leader in the race to prevent, treat or cure these epidemic diseases through the use of exciting new genomic-based technologies."

Mark A. Tepper, Ph.D., President of CytRx's diabetes and obesity subsidiary commented, "Through our partnership with 3rd Millennium, we establish the scientific computing and informatics infrastructure necessary to conduct state-of-the-art molecular based drug discovery more rapidly and efficiently than we could do on our own."

"This partnership will allow CytRx to conserve resources and reach its business and scientific objectives faster than if they were to build in-house resources," said Richard Dweck, president of 3rd Millennium Inc. "Partnering with 3rd Millennium to establish the informatics infrastructure, as well as the optimum modeling and in silico screening approaches, is the most effective way for CytRx to move rapidly toward its goal of introducing obesity and diabetes therapies into the marketplace."

To accelerate CytRx's structure-based small molecule discovery program, 3rd Millennium will work with CytRx to establish their informatics infrastructure, virtual library construction , homology modeling and virtual screening workflow.

About 3rd Millennium
3rd Millennium Inc., a privately held company, located in Waltham, MA, is a leading life science informatics consultancy, integrator, and developer of information systems to support biopharmaceutical research and discovery. Additional information about 3rd Millennium's services can be obtained by visiting the company's website at www.3rdmill.com or by calling 1-888-3rdmill.